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Compositions:
Mixture of various juices.
Indications:
Soft Drink
Descriptions:
Taj mugal-e-ajam sharbat is a
combination of Mixture of various
juices.
Drugs that interact with grapefruit
and/or grapefruit juice (GJ) undergo
cytochrome p450 oxidative metabolism in
the intestinal wall or liver. GJ
contains various furanocoumarins which
have been demonstrated to affect the
cytochrome p450 (CYP) system (especially
at isoenzyme CYP3A4) by binding to the
isoenzyme as a substrate and impairing
first-pass metabolism, by direct
inactivation or inhibition of the enzyme
(mechanism-based inhibitors). The net
effect on the CYP enzymes from this
inhibition seems to be a selective
down-regulation of CYP3A4 in the small
intestine. For certain drugs which are
known to be CYP 3A4 metabolized, less
drug is metabolized prior to absorption,
and greater amounts of these drugs reach
the systemic circulation, leading to
higher blood levels, and potentially to
increases in therapeutic and/or toxic
effects.
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Quality
